Graphene sensors read stroke damage from the shape of brain electrical waves

In healthy cortex, these waves are normally accompanied by widening of blood vessels. In ischemic tissue they can trigger the opposite response, which worsens metabolic stress and lesion growth. In two stroke models in mice, the duration and shape of the waves scaled with local blood flow. This let the team distinguish relatively preserved cortex from severely ischemic regions within a single preparation.

Researchers at the University of Manchester, the Institute of Microelectronics of Barcelona (IMB-CNM, CSIC), the Catalan Institute of Nanoscience and Nanotechnology (ICN2) and Multi Channel Systems (Germany) have used graphene micro-transistor arrays to map how brain tissue is faring during an ischemic stroke. The arrays record the slow, DC-coupled electrical signals of cortical spreading depolarizations, waves of disrupted neuronal activity that add secondary injury after a stroke. The team paired the arrays with optical imaging of cerebral blood flow and oxygenation.In healthy cortex, these waves are normally accompanied by widening of blood vessels. In ischemic tissue they can trigger the opposite response, which worsens metabolic stress and lesion growth. In two stroke models in mice, the duration and shape of the waves scaled with local blood flow. This let the team distinguish relatively preserved cortex from severely ischemic regions within a single preparation.

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​Graphene sensors read stroke damage from the shape of brain electrical waves

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Graphene sensors read stroke damage from the shape of brain electrical waves