Laser-induced graphene patch delivers noninvasive, low-temperature melanoma therapy

Researchers from Wuhan University and City University of Hong Kong have reported a soft, transparent, and stretchable laser-induced graphene (LIG)-Cu/PDMS patch that delivers noninvasive, low-temperature photothermal therapy for melanoma while simultaneously activating multiple programmed cell death pathways.

Melanoma causes over 80% of skin cancer-related deaths, and its aggressiveness, metastasis and drug resistance limit conventional surgery and chemoradiotherapy. The new patch is a bandage-like construct in which CuO-embedded LIG acts as the active therapeutic layer and polydimethylsiloxane (PDMS) provides a biocompatible, breathable, conformable matrix. Chemically inert and soft on the skin, the LIG-Cu/PDMS hybrid is fabricated via a cold-transfer method, remaining transparent and stretchable and enabling intimate contact, repeated use and potentially prolonged Cu²⁺ release under controlled stimulation.

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